top of page

FASTEN
STUDIEN-SAMMLUNG

Yoshinori Ohsumi
Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets.[Epilepsia. 2008]
The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism.[Prostaglandins Leukot Essent F...]
Ketone bodies in epilepsy.[J Neurochem. 2012]
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.[BMC Cancer. 2011]
Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet.[J Cancer Res Ther. 2009]

Cited by other articles in PMC

Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters[Scientific Reports. 2017]
Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species[The International Journal of B...]
Sirt6 alters adult hippocampal neurogenesis[PLoS ONE. 2017]
Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle[NPJ Aging and Mechanisms of Di...]
Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status?[International Journal of Endoc...]

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning.[Physiol Behav. 1993]
Review Gene-diet interactions in brain aging and neurodegenerative disorders.[Ann Intern Med. 2003]
Review Calorie restriction, SIRT1 and metabolism: understanding longevity.[Nat Rev Mol Cell Biol. 2005]
Review Calorie restriction--the SIR2 connection.[Cell. 2005]
Review Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses.[Trends Neurosci. 2006]
Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose.[Epilepsia. 2001]
Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies.[Nutr Metab (Lond). 2004]
Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet.[Epilepsy Res. 2003]
Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo.[Epilepsia. 2003]
Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults.[Ann Neurol. 1999]

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease.[J Neurosci Res. 1999]
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.[Proc Natl Acad Sci U S A. 2004]
Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults.[Ann Neurol. 1999]
Review Effects of energy balance on cancer in genetically altered mice.[J Nutr. 2004]
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).[J Alzheimers Dis. 2006]
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.[J Biol Chem. 2006]

Caloric restriction and spatial learning in old mice.[Physiol Behav. 1996]
Life-long diet restriction failed to retard cognitive aging in Fischer-344 rats.[Neurobiol Aging. 1999]
Impairment of water maze behaviour with ageing is counteracted by maze learning earlier in life but not by physical exercise, food restriction or housing conditions.[Exp Gerontol. 2006]
Long-term dietary restriction causes negative effects on cognitive functions in rats.[Neurobiol Aging. 2004]
Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease.[J Mol Neurosci. 1999]
No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice.[Brain Res. 1999]

Review Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.[Toxicol Appl Pharmacol. 2007]
Review Hormesis defined.[Ageing Res Rev. 2008]
Review Dietary factors, hormesis and health.[Ageing Res Rev. 2008]
Review Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses.[Trends Neurosci. 2006]
Review Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems.[J Nutr Biochem. 2005]
Review Caloric restriction and intermittent fasting: two potential diets for successful brain aging.[Ageing Res Rev. 2006]

Review Mitochondrial formation of reactive oxygen species.[J Physiol. 2003]
Review Bioenergetics of aging and calorie restriction.[Ageing Res Rev. 2006]
Review Mitochondria, oxidants, and aging.[Cell. 2005]
Review Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.[Curr Mol Med. 2004]
Evidence of increased oxidative damage in subjects with mild cognitive impairment.[Neurology. 2005]
Review Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.[J Chromatogr B Analyt Technol Biomed Life Sci. 2005]

Review Oxidative stress and mitochondrial function with aging--the effects of calorie restriction.[Aging Cell. 2004]
Review Bioenergetics of aging and calorie restriction.[Ageing Res Rev. 2006]
Antioxidant enzyme activities in lens, liver and kidney of calorie restricted Emory mice.[Mech Ageing Dev. 1997]
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle.[Am J Physiol Endocrinol Metab. 2002]
Caloric restriction augments ROS defense in S. cerevisiae, by a Sir2p independent mechanism.[Free Radic Res. 2005]
Energy restriction but not protein source affects antioxidant capacity in athletes.[Free Radic Biol Med. 2006]

Review Ageing, oxidative stress, and mitochondrial uncoupling.[Acta Physiol Scand. 2004]
Review Mitochondrial uncoupling proteins in the CNS: in support of function and survival.[Nat Rev Neurosci. 2005]
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria.[Am J Physiol Endocrinol Metab. 2005]

Review Calorie restriction increases life span: a molecular mechanism.[Nutr Rev. 2006]
Energy restriction reduces metabolic rate in adult male Fisher-344 rats.[J Nutr. 1993]
Energy expenditure of rats subjected to long-term food restriction.[Int J Food Sci Nutr. 2001]
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle.[Am J Physiol Endocrinol Metab. 2002]
Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart.[Am J Physiol Regul Integr Comp Physiol. 2003]
Action of food restriction in delaying the aging process.[Proc Natl Acad Sci U S A. 1982]

Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.[Endocrinology. 2003]
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.[Science. 2005]
Review Effects of energy balance on cancer in genetically altered mice.[J Nutr. 2004]

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.[Nature. 2000]
Review The biochemistry of sirtuins.[Annu Rev Biochem. 2006]
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.[Genes Dev. 1999]
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.[Science. 2000]
Calorie restriction extends yeast life span by lowering the level of NADH.[Genes Dev. 2004]
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.[Nature. 2001]

Sir2 blocks extreme life-span extension.[Cell. 2005]

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.[Science. 2004]
Resveratrol improves health and survival of mice on a high-calorie diet.[Nature. 2006]
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).[J Alzheimers Dis. 2006]
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.[J Biol Chem. 2006]
Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death.[Free Radic Biol Med. 2003]
Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity.[Gerontology. 2003]
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.[Nat Genet. 2005]
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.[Science. 2004]

Review Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.[J Neurochem. 2003]
Review Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).[J Pharmacol Sci. 2005]
Review Caloric restriction and intermittent fasting: two potential diets for successful brain aging.[Ageing Res Rev. 2006]
Negative control of p53 by Sir2alpha promotes cell survival under stress.[Cell. 2001]
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.[Cell. 2001]
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.[Free Radic Biol Med. 2006]

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.[Nature. 2004]
Review Calorie restriction--the SIR2 connection.[Cell. 2005]
Review PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases.[Biochem Soc Trans. 2006]
Review PPARgamma as a therapeutic target in central nervous system diseases.[Neurochem Int. 2006]
Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity.[Brain Res. 2006]
The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.[J Neuropathol Exp Neurol. 2005]

Review Emerging roles of PPARs in inflammation and immunity.[Nat Rev Immunol. 2002]
Activation of nuclear factor-kappaB signaling pathway by interleukin-1 after hypoxia/ischemia in neonatal rat hippocampus and cortex.[J Neurochem. 2005]
The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.[J Neuropathol Exp Neurol. 2005]
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.[EMBO J. 2004]
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.[Proc Natl Acad Sci U S A. 1995]
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.[J Neurosci Res. 1997]
Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons.[J Neurosci. 1998]

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage.[J Neurosci. 1992]
Review Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.[J Alzheimers Dis. 2005]
Review The insulin-like growth factor system and its pleiotropic functions in brain.[Endocr Rev. 2005]
Review SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox.[Neurobiol Aging. 2006]

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.[J Mol Neurosci. 2000]
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice.[J Neurochem. 2002]
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice.[Proc Natl Acad Sci U S A. 2003]
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.[Proc Natl Acad Sci U S A. 2004]
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning.[Neuroscience. 2002]
Review Energy intake, meal frequency, and health: a neurobiological perspective.[Annu Rev Nutr. 2005]
Review Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview.[Auton Neurosci. 2006]

Review Molecular chaperones in the cytosol: from nascent chain to folded protein.[Science. 2002]
Review Pathways of chaperone-mediated protein folding in the cytosol.[Nat Rev Mol Cell Biol. 2004]
Review Protein misfolding in neurodegenerative diseases.[Neuropathol Appl Neurobiol. 2004]

Expression of heat shock genes in hepatocytes is affected by age and food restriction in rats.[J Nutr. 1995]
Caloric restriction increases the expression of heat shock protein in the gut.[Ann Surg. 1996]
Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages.[Mech Ageing Dev. 1998]

Review Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction.[Microsc Res Tech. 2002]
Review Molecular mechanisms of aging-associated inflammation.[Cancer Lett. 2006]

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice.[Mech Ageing Dev. 1997]
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.[FASEB J. 2004]
Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet.[Biochem Biophys Res Commun. 2006]
Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.[J Gerontol A Biol Sci Med Sci. 2006]
Anti-inflammatory action of dietary fish oil and calorie restriction.[Life Sci. 2006]
Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-alpha, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats.[J Nutr Biochem. 2007]

Review Integrating cell-signalling pathways with NF-kappaB and IKK function.[Nat Rev Mol Cell Biol. 2007]
Review Signaling via NF-kappaB in the nervous system.[Biochim Biophys Acta. 2005]

Review Neural stem cells as therapeutic agents for age-related brain repair.[Aging Cell. 2004]
Review Potential role for adult neurogenesis in the encoding of time in new memories.[Nat Neurosci. 2006]
Review Adult neurogenesis and functional plasticity in neuronal circuits.[Nat Rev Neurosci. 2006]

Review Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.[J Neurochem. 2003]
Review Energy intake, meal frequency, and health: a neurobiological perspective.[Annu Rev Nutr. 2005]
Review Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies.[J Neurochem. 2003]
Review More fat and fewer seizures: dietary therapies for epilepsy.[Lancet Neurol. 2004]
Review Neuroprotective and disease-modifying effects of the ketogenic diet.[Behav Pharmacol. 2006]

The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children.[Pediatrics. 1998]
A multicenter study of the efficacy of the ketogenic diet.[Arch Neurol. 1998]
Review Ketogenic diet for the treatment of refractory epilepsy in children: A systematic review of efficacy.[Pediatrics. 2000]

Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats.[Epilepsia. 1997]
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.[Epilepsia. 1999]
The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy.[Epilepsia. 2000]

Experience with the ketogenic diet in infants.[Pediatrics. 2001]
Effects of ketogenic diet on development and behavior: preliminary report of a prospective study.[Dev Med Child Neurol. 2001]
Detrimental effects of the ketogenic diet on cognitive function in rats.[Pediatr Res. 2004]

Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.[Neurology. 2005]
Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study.[Neurology. 2005]
Effects of beta-hydroxybutyrate on cognition in memory-impaired adults.[Neurobiol Aging. 2004]
Application of a ketogenic diet in children with autistic behavior: pilot study.[J Child Neurol. 2003]

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.[Nutr Metab (Lond). 2005]
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.[J Neurosci Res. 2005]
Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats.[Neurosci Lett. 2005]

The ketogenic diet increases mitochondrial uncoupling protein levels and activity.[Ann Neurol. 2004]
Ketogenic diet increases glutathione peroxidase activity in rat hippocampus.[Neurochem Res. 2003]
Chronic ketosis and cerebral metabolism.[Ann Neurol. 1978]
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.[Ann Neurol. 2006]
Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.[Epilepsy Res. 2005]

The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice.[Epilepsy Res. 2003]
Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.[Epilepsy Res. 2005]
Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.[Brain Res. 2005]
Ketogenic diet protects the hippocampus from kainic acid toxicity by inhibiting the dissociation of bad from 14-3-3.[J Neurosci Res. 2006]
Caloric restriction augments brain glutamic acid decarboxylase-65 and -67 expression.[J Neurosci Res. 2004]
The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy.[Epilepsy Res. 2005]

Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet.[Neurology. 2003]
Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats.[Metabolism. 2005]
Review Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection.[Curr Opin Clin Nutr Metab Care. 2007]

Review Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes.[Diabetes Metab Res Rev. 1999]
Review Ketone body synthesis in the brain: possible neuroprotective effects.[Prostaglandins Leukot Essent Fatty Acids. 2004]

Differences in circulating gluconeogenic substrates during short-term fasting in men, women, and children.[Metabolism. 1982]
Fasting studies in cerebrospinal fluid and blood in children with epilepsy of unknown origin.[Epilepsy Res. 1995]
Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet.[MAGMA. 1999]

Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo.[Epilepsia. 2002]

D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.[J Clin Invest. 2003]
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.[Proc Natl Acad Sci U S A. 2000]
D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease.[J Neurosci Res. 2006]
Effects of beta-hydroxybutyrate on cognition in memory-impaired adults.[Neurobiol Aging. 2004]

Review Neurodegenerative diseases and oxidative stress.[Biomed Pharmacother. 2004]
Review Ageing and neuronal vulnerability.[Nat Rev Neurosci. 2006]
Review Mitochondrial permeability transition and oxidative stress.[FEBS Lett. 2001]

Acetoacetate protects neuronal cells from oxidative glutamate toxicity.[J Neurosci Res. 2006]

Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.[Neurology. 2000]
Acetoacetate protects neuronal cells from oxidative glutamate toxicity.[J Neurosci Res. 2006]

Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons.[Biochem J. 1992]
Characterization of superoxide-producing sites in isolated brain mitochondria.[J Biol Chem. 2004]
Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.[J Comp Neurol. 2004]
Review Mitochondrial formation of reactive oxygen species.[J Physiol. 2003]

Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.[Jpn J Pharmacol. 2001]
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.[J Clin Invest. 2003]
Review Ketone bodies, potential therapeutic uses.[IUBMB Life. 2001]

Review Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.[J Neurochem. 2003]
Review Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.[Curr Mol Med. 2004]
Review Mitochondria, oxidants, and aging.[Cell. 2005]

Review Protein phosphatase 2A: a panoply of enzymes.[Curr Opin Cell Biol. 2000]
Review Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.[Biochem J. 2001]
A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis.[J Biol Chem. 2003]
Review Mitochondrial membrane permeabilization in cell death.[Physiol Rev. 2007]

Review Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.[J Neurochem. 2003]
Review Calorie restriction mimetics: an emerging research field.[Aging Cell. 2006]
Review Effects of energy balance on cancer in genetically altered mice.[J Nutr. 2004]
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.
[Nutr Metab (Lond). 2007]

bottom of page